Background Atopic dermatitis (AD) is characterized by a skin barrier defect aggravated by
mechanical injury inflicted by scratching, a TH 2 cell–dominated immune response, and …

Naive CD4+ T cell differentiation into distinct subsets of T helper (Th) cells is a pivotal
process in the initiation of the adaptive immune response. Allergens predominantly stimulate …

IFN-α is an important cytokine for the generation of a protective T cell-mediated immune
response to viruses. In this study, we asked whether IFN-α can regulate the functional …

The method of choice for the development of new vaccines is to target distinct dendritic cell
subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated …

Recently, it has become clear that dendritic cells (DCs) are essential for the priming of T cell
responses. However, their role in the maintenance of peripheral T cell tolerance remains …

Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear
which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably …

BACKGROUND: IL-10 affects dendritic cell (DC) function, but the effects on airway
hyperresponsiveness (AHR) and inflammation are not defined. OBJECTIVE: We sought to …

Background: IL-10-inducing adjuvants could enhance the efficacy of allergy vaccines in
establishing allergen-specific tolerance. The aim of this study wasto identify such adjuvants …

Dendritic cells (DC) are the main orchestrators of specific immune responses. Depending on
microbial information they encounter in peripheral tissues, they promote the development of …

Dendritic cells (DC) are potent antigen–presenting cells that can orientate the immune
response towards a Th1 or a Th2 type. DC produce chemokines that are involved in the …