Abstract IL-10–differentiated dendritic cells (DC10) induce allergen tolerance in asthmatic
mice, during which their lung Th2 effector T cells (Teffs) are displaced by activated CD4+ …

Adaptive immune responses are orchestrated by specialized professional antigen-
presenting cells (APCs), the dendritic cells (DCs), which play crucial roles as initiators and …

Dendritic cells (DC) are antigen-presenting cells that can communicate with T cells both
directly and indirectly, regulating our adaptive immune responses against environmental …

The prevalence rate of allergic diseases, such as asthma, atopic rhinitis (AR), and atopic
dermatitis (AD), has been significantly increasing over the years because of environmental …

Background Distinct human IL-10–producing B-cell subsets with immunoregulatory
properties have been described. However, the broader spectrum of their direct cellular …

Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17
and innate lymphoid cells also in regulating airway inflammation. Herein, we have …

Allergic asthma is characterized by airway hyper‐responsiveness and chronic mucosal
inflammation mediated by CD4+ Th2 lymphocytes. Regulatory CD4+ CD25+ T cells are …

Human studies demonstrated that allergen-specific immunotherapy (IT) represents an
effective treatment for allergic diseases. IT involves repeated administration of the …

Allergen-specific immunotherapy has been used for 100 years as a desensitizing therapy for
allergic diseases and represents the potentially curative and specific method of treatment …

BACKGROUND: In allergic rhinitis (AR) CD4+ TH2 lymphocytes control inflammation by
secreting TH2 cytokines, but little is known about how these cells are activated to cause …