A critical aim of vaccine‐related research is to identify the mechanisms by which memory T
cells are formed and maintained over long periods of time. In recent years, we have …

Generating long-lasting, protective CD8+ T-cell memory via vaccination is critical for
combating infectious diseases. Advances in the past year have provided many new insights …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …

CD8+ T cells play a crucial role in controlling intracellular pathogens. The level of memory
CD8+ T cells developing after vaccination or infection influences the degree of T cell …

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore
it is imperative to define the parameters that regulate the development and preservation of …

Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

The role of CD4 T cells in providing help to CD8 T cells in primary and secondary responses
to infection remains controversial. Using recombinant strains of virus and bacteria …

Immunological memory is one of the features that define the adaptive immune response: by
generating specific memory cells after infection or vaccination, the host provides itself with a …

M emory T-cell responses are of vital importance in understanding the host's immune
response against pathogens and cancer cells and to begin establishing the correlation of …

Abstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent …