Murine cytomegalovirus regulation of NKG2D ligands

T Lenac, J Arapović, L Traven, A Krmpotić… - Medical microbiology and …, 2008 - Springer
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes morbidity risk in
immunologically suppressed and immunodeficient patients including congenital infections …

Genetic variability of human cytomegalovirus clinical isolates correlates with altered expression of natural killer cell-activating ligands and IFN-γ

G Galitska, A Coscia, D Forni, L Steinbrueck… - Frontiers in …, 2021 - frontiersin.org
Human cytomegalovirus (HCMV) infection often leads to systemic disease in
immunodeficient patients and congenitally infected children. Despite its clinical significance …

Genetic control of innate immune responses against cytomegalovirus: MCMV meets its match

JR Webb, SH Lee, SM Vidal - Genes & Immunity, 2002 - nature.com
Cytomegalovirus (CMV) is a widespread pathogen that is responsible for severe disease in
immunocompromised individuals and probably, associated with vascular disease in the …

NK cell receptors and their MHC class I ligands in host response to cytomegalovirus: insights from the mouse genome

M Pyzik, A Kielczewska, SM Vidal - Seminars in immunology, 2008 - Elsevier
The complex interaction between natural killer (NK) cells and cytomegalovirus is a paradigm
of the co-evolution between genomes of large DNA viruses and their host immune systems …

Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands

S Müller, G Zocher, A Steinle, T Stehle - PLoS pathogens, 2010 - journals.plos.org
The activating immunoreceptor NKG2D promotes elimination of infected or malignant cells
by cytotoxic lymphocytes through engagement of stress-induced MHC class I-related …

Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18

V Prod'homme, P Tomasec, C Cunningham… - The Journal of …, 2012 - journals.aai.org
Abstract Human CMV (HCMV)-encoded NK cell-evasion functions include an MHC class I
homolog (UL18) with high affinity for the leukocyte inhibitory receptor-1 (CD85j, ILT2, or …

Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142

NJ Chalupny, A Rein-Weston, S Dosch… - … and biophysical research …, 2006 - Elsevier
Human cytomegalovirus (HCMV) employs a variety of strategies to modify or evade the host
immune response, and natural killer (NK) cells play a crucial role in controlling …

The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins

J Odeberg, H Browne, S Metkar, CJ Froelich… - Journal of …, 2003 - Am Soc Microbiol
Several reports have shown that human cytomegalovirus (HCMV)-infected cells are resistant
to NK lysis. These studies have focused on receptor-ligand interactions, and different HCMV …

Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR‐1/ILT2/CD85j

C Cerboni, A Achour, A Wärnmark… - European journal of …, 2006 - Wiley Online Library
Human cytomegalovirus (HCMV) down‐regulates cell surface expression of HLA class I
molecules (HLA‐I). UL18, an HCMV‐encoded HLA‐I homologue, has been proposed to …

Structural insights into activation of antiviral NK cell responses

KA Finton, RK Strong - Immunological reviews, 2012 - Wiley Online Library
Natural killer (NK) cells are key components of innate immune responses, providing
surveillance against cells undergoing tumorigenesis or infection, by viruses or internal …