The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60–NKG2D interactions

MB Lodoen, G Abenes, S Umamoto… - The Journal of …, 2004 - rupress.org
Natural killer (NK) cells are an important early mediator of host immunity to murine
cytomegalovirus (MCMV) infection. However, MCMV has evolved mechanisms to elude …

The CD94/NKG2C+ NK-cell subset on the edge of innate and adaptive immunity to human cytomegalovirus infection

M López-Botet, A Muntasell, C Vilches - Seminars in immunology, 2014 - Elsevier
Human cytomegalovirus (HCMV) causes a highly prevalent and lifelong infection, with a
multifaceted impact in human health. NK cells play an important role in the immune …

NK Cell Receptor/H2-Dk–Dependent Host Resistance to Viral Infection Is Quantitatively Modulated by H2q Inhibitory Signals

N Fodil-Cornu, JC Loredo-Osti, SM Vidal - PLoS Genetics, 2011 - journals.plos.org
The cytomegalovirus resistance locus Cmv3 has been linked to an epistatic interaction
between two loci: a Natural Killer (NK) cell receptor gene and the major histocompatibility …

The human cytomegalovirus MHC class I homolog UL18 inhibits LIR-1+ but activates LIR-1− NK cells

V Prod'homme, C Griffin, RJ Aicheler… - The Journal of …, 2007 - journals.aai.org
The inhibitory leukocyte Ig-like receptor 1 (LIR-1, also known as ILT2, CD85j, or LILRB1)
was identified by its high affinity for the human CMV (HCMV) MHC class I homolog gpUL18 …

Biology and clinical relevance of HCMV-associated adaptive NK cells

F Gao, Z Zhou, Y Lin, G Shu, G Yin… - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer (NK) cells are an important component of the innate immune system due to
their strong ability to kill virally infected or transformed cells without prior exposure to the …

Synergistic effect of IFN‐γ and human cytomegalovirus protein UL40 in the HLA‐E‐dependent protection from NK cell‐mediated cytotoxicity

C Cerboni, M Mousavi‐Jazi… - European journal of …, 2001 - Wiley Online Library
Human CMV (HCMV) has evolved several strategies to evade the immune system of the
infected host. Here, we investigated the role of the HCMV‐encoded protein UL40 in the …

Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP) 1 and ULBP2 is …

A Rölle, M Mousavi-Jazi, M Eriksson… - The Journal of …, 2003 - journals.aai.org
Human CMV (HCMV) interferes with NK cell functions at various levels. The HCMV
glycoprotein UL16 binds some of the ligands recognized by the NK-activating receptor …

Immune evasion by human cytomegalovirus: lessons in immunology and cell biology

WAM Loenen, CA Bruggeman, E Wiertz - Seminars in immunology, 2001 - Elsevier
The human cytomegalovirus (HCMV) has dedicated a significant part of its genome to genes
encoding molecules that modulate the host immune response. Many of these genes have …

Characterization of murine cytomegalovirus m157 from infected cells and identification of critical residues mediating recognition by the NK cell receptor Ly49H

AH Davis, NV Guseva, BL Ball… - The Journal of …, 2008 - journals.aai.org
Activated NK cells mediate potent cytolytic and secretory effector functions and are vital
components of the early antiviral immune response. NK cell activities are regulated by the …

MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo

A Krmpotić, DH Busch, I Bubić, F Gebhardt… - Nature …, 2002 - nature.com
The susceptibility of certain inbred mouse strains to murine cytomegalovirus (MCMV) is
related to their inability to generate a strong natural killer (NK) cell response. We addressed …