Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged
receptors, a hallmark of adaptive lymphocytes. In some people infected with human …

Both human and mouse cytomegaloviruses (CMVs) encode proteins that inhibit the
activation of NK cells by down-regulating cellular ligands for the activating NK cell receptor …

The HCMV genome has evolved with its host by incorporating a series of genes that are
homologous to, or functionally mimic, cellular genes. Some are designed to counteract the …

Natural killer (NK) cells play a critical role in controlling murine cytomegalovirus (MCMV)
and can mediate both cytokine production and direct cytotoxicity. The NK cell activation …

The MHC-encoded MHC class I-related chains A (MICA) glycoproteins are known to
enhance the functions of NK and T cells by ligating the stimulating receptor NKG2D and …

Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-
mediated cytolysis by downregulating cell surface expression of CD155 (nectin-like …

Clinical and low passage strains of human CMV (HCMV) encode an additional MHC class I-
related molecule UL142, in addition to the previously described UL18. The UL142 open …

Natural killer (NK) cells have been implicated in early immune responses against certain
viruses, including cytomegalovirus (CMV). CMV causes downregulation of class I major …

NK cells play a major role in immune defense against human and murine CMV (MCMV)
infection. Although the MCMV genome encodes for MHC class I–homologous decoy ligands …

Natural killer (NK) cell recognition of the nonclassical human leukocyte antigen (HLA)
molecule HLA-E is dependent on the presentation of a nonamer peptide derived from the …