In mouse models of asthma, therapeutic use of allergen-presenting IL-10–differentiated
dendritic cells (DCs) can abrogate airway hyperresponsiveness, and reduce other asthma …

Abstract IL-10–differentiated dendritic cells (DC10s) can prevent allergen sensitization and
reverse the asthma phenotype in mice with established disease. However, little is known …

Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary
immune responses, including tolerogenic responses. We have genetically engineered bone …

To cite this article: Lu M, Dawicki W, Zhang X, Huang H, Nayyar A, Gordon JR. Therapeutic
induction of tolerance by IL‐10‐differentiated dendritic cells in a mouse model of house dust …

Splenic CD8α+ dendritic cells reportedly tolerize T cell responses by inducing Fas ligand-
mediated apoptosis, suppressing IL-2 expression, or catabolizing T cell tryptophan reserves …

Rationale: Tolerogenic dendritic cells and natural regulatory T cells have been implicated in
the process of infectious tolerance in human allergic asthma. However, the significance of …

Background Allergen‐presenting dendritic cells differentiated with IL‐10 (DC 10) reverse the
asthma phenotype in mice by converting their Th2 cells to regulatory T cells (T regs). DC 10 …

Department of Allergy, Chonnam National University Medical School, Gwangju, Korea 5%-
10% of peripheral CD4+ T cells and express CD4, CD25, and Foxp3 on their surface, but …

Allergic asthma is one of the most common chronic diseases in western society,
characterized by variable airway obstruction, mucus hypersecretion and infiltration of the …

Although dendritic cells (DCs) play an important role in sensitization to inhaled allergens,
their function in ongoing T helper (Th) 2 cell–mediated eosinophilic airway inflammation …