Early clinical investigations of candidate malaria vaccines and antimalarial medications
increasingly employ an established model of controlled human malaria infection (CHMI) …

Background Controlled human malaria infection (CHMI) studies which recapitulate mosquito-
borne infection are a critical tool to identify protective vaccine and drug candidates for …

Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

Human experimentation by deliberate infection with malarial parasites seems unethical yet
has a long history in infectious disease research. After rigorous screening, volunteers are …

Background Exposing healthy human volunteers to Plasmodium falciparum-infected
mosquitoes is an accepted tool to evaluate preliminary efficacy of malaria vaccines. To …

Over a century since Ronald Ross discovered that malaria is caused by the bite of an
infectious mosquito it is still unclear how the number of parasites injected influences disease …

Malaria is one of the most frequently occurring infectious diseases worldwide, with almost 1
million deaths and an estimated 243 million clinical cases annually. Several candidate …

Malaria draws global attention in a cyclic manner, with interest and associated financing
waxing and waning according to political and humanitarian concerns. Currently we are on …

Controlled human malaria infection (CHMI) is a powerful tool to evaluate the efficacy of
malaria vaccines and pharmacologics. Investigators at the University of Maryland, Baltimore …

Introduction: An effective vaccine against malaria forms a global health priority. Both
naturally acquired immunity and sterile protection induced by irradiated sporozoite …