Involvement of synaptic genes in the pathogenesis of autism spectrum disorders: the case of synapsins

S Giovedí, A Corradi, A Fassio, F Benfenati - Frontiers in pediatrics, 2014 - frontiersin.org
Autism spectrum disorders (ASDs) are heterogeneous neurodevelopmental disorders
characterized by deficits in social interaction and social communication, restricted interests …

Autism spectrum disorder: signaling pathways and prospective therapeutic targets

J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …

An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity

E Masini, E Loi, AF Vega-Benedetti, M Carta… - International journal of …, 2020 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects social
interaction and communication, with restricted interests, activity and behaviors. ASD is highly …

Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders

E Santini, E Klann - Science signaling, 2014 - science.org
Autism spectrum disorder (ASD) is a heterogeneous group of heritable neurodevelopmental
disorders. Symptoms of ASD, which include deficits in social interaction skills, impaired …

Abnormal development of the earliest cortical circuits in a mouse model of autism spectrum disorder

DA Nagode, X Meng, DE Winkowski, E Smith… - Cell reports, 2017 - cell.com
Autism spectrum disorder (ASD) involves deficits in speech and sound processing. Cortical
circuit changes during early development likely contribute to such deficits. Subplate neurons …

Multiple rare variants in the etiology of autism spectrum disorders

JD Buxbaum - Dialogues in clinical neuroscience, 2009 - Taylor & Francis
Recent studies in autism spectrum disorders (ASDs) support an important role for multiple
rare variants in these conditions. This is a clinically important finding, as, with the …

Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease

S Watanabe, T Kurotani, T Oga, J Noguchi… - Nature …, 2021 - nature.com
Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and
gene expression changes. Early intervention during childhood is thought to benefit …

[HTML][HTML] A short review on the current understanding of autism spectrum disorders

HR Park, JM Lee, HE Moon, DS Lee… - Experimental …, 2016 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by
a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial …

First glimpses of the neurobiology of autism spectrum disorder

SJ Sanders - Current opinion in genetics & development, 2015 - Elsevier
Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has
provided the substrate for a first wave of analyses into the underlying neurobiology. This …

Getting to the cores of autism

LM Iakoucheva, AR Muotri, J Sebat - Cell, 2019 - cell.com
The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allelic
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …