Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders

W Spooren, L Lindemann, A Ghosh… - Trends in pharmacological …, 2012 - cell.com
Autism and autism spectrum disorders (ASDs) affect millions of individuals worldwide.
Despite increased autism diagnoses over the past 30 years, therapeutic intervention is often …

Genetics of autism spectrum disorders

RA Kumar, SL Christian - Current neurology and neuroscience reports, 2009 - Springer
Autism spectrum disorders (ASDs) are a clinically complex group of childhood disorders that
have firm evidence of an underlying genetic etiology. Many techniques have been used to …

Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

From the genetic architecture to synaptic plasticity in autism spectrum disorder

T Bourgeron - Nature Reviews Neuroscience, 2015 - nature.com
Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been …

Molecular mechanisms of autism: a possible role for Ca2+ signaling

JF Krey, RE Dolmetsch - Current opinion in neurobiology, 2007 - Elsevier
Autism spectrum disorders (ASDs) are a group of developmental disorders characterized by
social and emotional deficits, language impairments and stereotyped behaviors that …

[HTML][HTML] Current knowledge on the genetics of autism and propositions for future research

T Bourgeron - Comptes rendus biologies, 2016 - Elsevier
Autism spectrum disorders (ASD) are a heterogeneous group of neuropsychiatric disorders
characterized by problems in social communication, as well as by the presence of restricted …

Disrupted brain network in children with autism spectrum disorder

K Zeng, J Kang, G Ouyang, J Li, J Han, Y Wang… - Scientific reports, 2017 - nature.com
Alterations in brain connectivity have been extensively reported in autism spectrum disorder
(ASD), while their effects on the topology of brain network are still unclear. This study …

The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

C Betancur, T Sakurai, JD Buxbaum - Trends in neurosciences, 2009 - cell.com
Recent advances in genetics and genomics have unveiled numerous cases of autism
spectrum disorders (ASDs) associated with rare, causal genetic variations. These findings …

Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD)

M Nguyen, A Roth, EJ Kyzar, MK Poudel… - Neurochemistry …, 2014 - Elsevier
Autism spectrum disorder (ASD) is a debilitating brain illness causing social deficits, delayed
development and repetitive behaviors. ASD is a heritable neurodevelopmental disorder with …

Environmental and genetic factors in autism spectrum disorders: special emphasis on data from Arabian studies

NB Almandil, DN Alkuroud, S AbdulAzeez… - International journal of …, 2019 - mdpi.com
One of the most common neurodevelopmental disorders worldwide is autism spectrum
disorder (ASD), which is characterized by language delay, impaired communication …