Autism genetics–an overview

J Yin, CP Schaaf - Prenatal diagnosis, 2017 - Wiley Online Library
Autism spectrum disorder (ASD) is a highly heritable, clinically diverse group of
neurodevelopmental disorders. Its genetic heterogeneity is remarkable, with more than 800 …

Striatal circuits as a common node for autism pathophysiology

MV Fuccillo - Frontiers in neuroscience, 2016 - frontiersin.org
Autism spectrum disorders (ASD) are characterized by two seemingly unrelated symptom
domains—deficits in social interactions and restrictive, repetitive patterns of behavioral …

Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Y Xiong, J Chen, Y Li - Frontiers in Neuroscience, 2023 - frontiersin.org
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with onset in
childhood. The mechanisms underlying ASD are unclear. In recent years, the role of …

Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1

E Fujita, H Dai, Y Tanabe, Y Zhiling, T Yamagata… - Cell death & …, 2010 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an unknown
molecular pathogenesis. A recent molecular focus has been the mutated neuroligin 3 …

Autism spectrum disorders: etiology and pathology

AK Sauer, J Stanton, S Hans… - Exon Publications, 2021 - exonpublications.com
Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases. The cause
of ASD is unknown, but several genetic and non-genetic risk factors have been …

Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Neocortical neurogenesis and the etiology of autism spectrum disorder

A Packer - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Researchers have now identified many highly penetrant genetic risk factors for autism
spectrum disorder (ASD). Some of these genes encode synaptic proteins, lending support to …

Advances in understanding the pathophysiology of autism spectrum disorders

K Yenkoyan, A Grigoryan, K Fereshetyan… - Behavioural brain …, 2017 - Elsevier
Autism spectrum disorders (ASD) are common heterogeneous neurodevelopmental
disorders with typical triad of symptoms: impaired social interaction, language and …

Disruption of an evolutionarily novel synaptic expression pattern in autism

X Liu, D Han, M Somel, X Jiang, H Hu, P Guijarro… - PLoS …, 2016 - journals.plos.org
Cognitive defects in autism spectrum disorder (ASD) include socialization and
communication: key behavioral capacities that separate humans from other species. Here …

Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders

J Jacob - Epilepsia, 2016 - Wiley Online Library
Autism and epilepsy are two associated disorders that are highly prevalent, share common
developmental origins, and demonstrate substantial heritability. In this review, cross …