Dysfunction of the corticostriatal pathway in autism spectrum disorders

W Li, L Pozzo‐Miller - Journal of neuroscience research, 2020 - Wiley Online Library
The corticostriatal pathway that carries sensory, motor, and limbic information to the striatum
plays a critical role in motor control, action selection, and reward. Dysfunction of this …

[HTML][HTML] Intracellular calcium dysregulation in autism spectrum disorder: an analysis of converging organelle signaling pathways

RL Nguyen, YV Medvedeva, TE Ayyagari… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Autism spectrum disorder (ASD) is a group of complex, neurological disorders that affect
early cognitive, social, and verbal development. Our understanding of ASD has vastly …

Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour

V Verma, A Paul, A Amrapali Vishwanath… - Open …, 2019 - royalsocietypublishing.org
Normal brain development is highly dependent on the timely coordinated actions of genetic
and environmental processes, and an aberration can lead to neurodevelopmental disorders …

Role of oligodendrocytes and myelin in the pathophysiology of autism spectrum disorder

AY Galvez-Contreras, D Zarate-Lopez… - Brain sciences, 2020 - mdpi.com
Autism Spectrum Disorder (ASD) is an early neurodevelopmental disorder that involves
deficits in interpersonal communication, social interaction, and repetitive behaviors …

Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder

JLR Rubenstein - Current opinion in neurology, 2010 - journals.lww.com
The genetic landscape of ASDs has several salient features [2–4]. ASDs are heritable–
concordance rates in monozygotic twins ($60–90%) are roughly ten-fold higher than in …

Autism spectrum disorders and neuropathology of the cerebellum

DR Hampson, GJ Blatt - Frontiers in neuroscience, 2015 - frontiersin.org
The cerebellum contains the largest number of neurons and synapses of any structure in the
central nervous system. The concept that the cerebellum is solely involved in fine motor …

Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

Q Wang, Y Kong, DY Wu, JH Liu, W Jie, QL You… - Nature …, 2021 - nature.com
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The
mechanisms underlying ASD are unclear. Astrocyte alterations are noted in ASD patients …

[HTML][HTML] Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits

G Tang, K Gudsnuk, SH Kuo, ML Cotrina, G Rosoklija… - Neuron, 2014 - cell.com
Developmental alterations of excitatory synapses are implicated in autism spectrum
disorders (ASDs). Here, we report increased dendritic spine density with reduced …

Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder

I Cusco, A Medrano, B Gener, M Vilardell… - Human Molecular …, 2009 - academic.oup.com
Autism spectrum disorders (ASDs) constitute a group of severe neurodevelopmental
conditions with complex multifactorial etiology. In order to explore the hypothesis that …

Advancing the understanding of autism disease mechanisms through genetics

L de la Torre-Ubieta, H Won, JL Stein… - Nature medicine, 2016 - nature.com
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …