Cerebellar and striatal implications in autism spectrum disorders: from clinical observations to animal models

M Thabault, V Turpin, A Maisterrena, M Jaber… - International Journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASD) are complex conditions that stem from a combination of
genetic, epigenetic and environmental influences during early pre-and postnatal childhood …

Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis

M Birtele, A Del Dosso, T Xu, T Nguyen… - Nature …, 2023 - nature.com
Genes involved in synaptic function are enriched among those with autism spectrum
disorder (ASD)-associated rare genetic variants. Dysregulated cortical neurogenesis has …

Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex

H Sacai, K Sakoori, K Konno, K Nagahama… - Nature …, 2020 - nature.com
Autism spectrum disorder (ASD) is thought to result from deviation from normal development
of neural circuits and synaptic function. Many genes with mutation in ASD patients have …

[HTML][HTML] High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways

HW Mendes, U Neelakantan, Y Liu, SE Fitzpatrick… - Cell reports, 2023 - cell.com
Advancing from gene discovery in autism spectrum disorders (ASDs) to the identification of
biologically relevant mechanisms remains a central challenge. Here, we perform parallel in …

Rare structural variation of synapse and neurotransmission genes in autism

X Gai, HM Xie, JC Perin, N Takahashi, K Murphy… - Molecular …, 2012 - nature.com
Autism spectrum disorders (ASDs) comprise a constellation of highly heritable
neuropsychiatric disorders. Genome-wide studies of autistic individuals have implicated …

[HTML][HTML] Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders

G Pintacuda, YHH Hsu, K Tsafou, KW Li, JM Martín… - Cell Genomics, 2023 - cell.com
Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in
the brain, but it is unclear how these genes converge into cell-type-specific networks. We …

Neuropathological mechanisms of seizures in autism spectrum disorder

RE Frye, MF Casanova, SH Fatemi… - Frontiers in …, 2016 - frontiersin.org
This manuscript reviews biological abnormalities shared by autism spectrum disorder (ASD)
and epilepsy. Two neuropathological findings are shared by ASD and epilepsy …

Dopaminergic dysregulation in syndromic autism spectrum disorders: insights from genetic mouse models

P Kosillo, HS Bateup - Frontiers in Neural Circuits, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by altered social
interaction and communication, and repetitive, restricted, inflexible behaviors. Approximately …

Neuronal and glial cell number is altered in a cortical layer-specific manner in autism

C Falcone, NY Mevises, T Hong, B Dufour, X Chen… - …, 2021 - journals.sagepub.com
Autism spectrum disorder is a neurodevelopmental condition characterized by impaired
social communication and repetitive behaviors. Changes in the number of specific cell types …

Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway

S Mencer, M Kartawy, F Lendenfeld, H Soluh… - Translational …, 2021 - nature.com
Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological
disorders that share common clinical features, such as language impairment, executive …