Tissue-resident memory CD8+ T (Trm) cells in the liver are critical for long-term protection
against pre-erythrocytic Plasmodium infection. Such protection can usually be induced with …

Sterile immunity against live Plasmodium infection can be achieved by immunization with
radiation-attenuated sporozoites. This protection is known to be mediated in part by antigen …

In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Immunity to Plasmodium liver stages in individuals in malaria-endemic areas is inextricably
linked to concomitant blood-stage parasitemia. Although Plasmodium sporozoite infection …

Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan
parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill …

Immunization with irradiated sporozoites is currently the most effective vaccination strategy
against liver stages of malaria parasites, yet the mechanisms underpinning the success of …

Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill
Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination …

Immunization with radiation (γ)-attenuated Plasmodia sporozoites (γ-spz) confers sterile and
long-lasting immunity against malaria liver-stage infection. In the P. berghei γ-spz model …

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been
used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria …

Sterile protection against infection with Plasmodium sporozoites requires high numbers of
memory CD8 T cells. However, infections with unrelated pathogens, as may occur in areas …