Memory CD8+ T cells are an important component of the adaptive immune response against
many infections, and understanding how Ag-specific memory CD8+ T cells are generated …

Immunological memory is a phenomenon where the immune system can respond more
rapidly to pathogens and immunological challenges that it has previously encountered. It is …

The ability of the adaptive immune system to form memory is key to providing protection
against secondary infections. Resident memory T cells (TRM) are specialized T cell …

Historically, most immune response studies have been limited to analyses of lymphoid
tissue. However, peripheral sites of infection are likely to represent important sites of cell …

Abstract C D8 T-cell responses play an important role in protection against intracellular
pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary …

The role of CD4 T cells in providing help to CD8 T cells in primary and secondary responses
to infection remains controversial. Using recombinant strains of virus and bacteria …

A fundamental benefit of immunological memory is the ability to respond in an enhanced
manner upon secondary encounter with the same pathogen. Tissue-resident memory CD8 T …

The development of immune memory mediated by T lymphocytes is central to durable, long‐
lasting protective immunity. A key issue in the field is how to direct the generation and …

During the last 10 years, a population of clonally expanded T cells that take up permanent
residence in non-lymphoid tissues has been identified. The localization of these tissue …

Immunological memory is characterized by the ability to provide protection from secondary
exposure to pathogens. CD8+ memory T cells provide protection from cell-associated …