Immunological memory is one of the defining features of the adaptive immune system. As
key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of …

CD8 T cells are pivotal for the control of many intracellular pathogens, and besides their role
in immediate control of infections, CD8 T cells have the capacity to differentiate into long …

The developmental pathways of long-lived memory CD8 T cells and the lineage relationship
between memory T cell subsets remain controversial. Although some studies indicate the …

Memory CD8 T cells provide durable protection against diverse intracellular pathogens and
can be broadly segregated into distinct circulating and tissue-resident populations …

Whether memory CD8 T cells can be reactivated in nonlymphoid tissues is unclear. Using
mice lacking the spleen, lymph nodes, or both, we show that the secondary T cell response …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

In response to infection, naive CD 4+ T‐cells proliferate and differentiate into several
possible effector subsets, including conventional T helper effector cells (TH 1, TH 2, TH 17) …

T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

Memory CD8+ T cells play an essential role in controlling pathogenic infections. Therefore
generating protective memory CD8+ T cells by vaccination is an attractive strategy for …

The small number of antigen-specific memory CD4 T cells surviving long-term after antigen
or pathogen challenge are often characterized by a surprising degree of phenotypic and …