Memory CD8 T cells confer increased protection to immune hosts upon secondary viral,
bacterial, and parasitic infections. The level of protection provided depends on the numbers …

How and when memory T cells form during an immune response are long-standing
questions. To better understand memory CD8 T cell development, a time course of gene …

The formation of memory CD8 T cells is an important goal of vaccination. However, although
widespread use of booster immunizations in humans generates secondary and tertiary CD8 …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …

Tissue-resident memory T cells (TRM) comprise a newly defined subset, which comprises a
major component of lymphocyte populations in diverse peripheral tissue sites, including …

While many aspects of memory T‐cell immunobiology have been characterized, we suggest
that we know only a fraction of the effector functions that CD4 T cells can bring to bear during …

The role of CD4 T cell help in primary and secondary CD8 T cell responses to infectious
pathogens remains incompletely defined. The primary CD8 T response to infections was …

In the course of an immune response to an infectious microbe, pathogen-specific naïve
CD4+ T cells proliferate extensively and differentiate into effector cells. Most of these cells …

Homeostatic control of CD8 T cell populations is essential for defense against infectious
pathogens. Our understanding of the mechanisms that control naı̈ve, effector and memory …

M emory T-cell responses are of vital importance in understanding the host's immune
response against pathogens and cancer cells and to begin establishing the correlation of …