In response to infection, antigen‐specific CD8+ T cells undergo massive expansion in
numbers, acquire effector mechanisms, and disseminate throughout the body. The …

Most memory CD8 T cell subsets that have been hitherto defined are generated in response
to infectious pathogens. In this study, we have characterized the CD8 T cells that survive …

Clonal expansion of virus-specific naive T cells during an acute viral infection results in the
formation of memory CD8 T cells that provide the host with long-term protective immunity …

Immune responses to infection are optimally designed to generate large numbers of effector
T cells while simultaneously minimizing the collateral damage of their potentially lethal …

CD4 T-cell memory is in some ways more enigmatic than CD8 T-cell memory. This is mostly
due to the fact that CD4 T cells tend to expand far less in response to antigenic stimuli …

In the face of emerging infectious diseases caused by rapidly evolving and highly virulent
pathogens, such as influenza, we are challenged to develop innovative vaccine strategies …

Memory T cells are crucial for both local and systemic protection against pathogens over a
long period of time. Three major subsets of memory T cells; effector memory T (TEM) cells …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

Following a primary immune response, a portion of effector T cells gives rise to long-lived
memory cells. Although primary expansion and differentiation of effector CD8 T cells is …

The size of the adaptive immune system is considered to be kept constant by the attrition of
pre-existing memory. However, recently it was shown that the CD8 memory compartment …