Microbial infection primes a CD8+ cytotoxic T cell response that gives rise to a long-lived
population of circulating memory cells able to provide protection against systemic …

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral
immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo …

Tissue-resident memory CD8+ T cells are an important first line of defense from infection in
peripheral non-lymphoid tissues, such as the mucosal tissues of the respiratory, digestive …

We have investigated the contribution of CD4 T cells to the optimal priming of functionally
robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice …

Memory CD8 T cells persist by Ag-independent homeostatic proliferation. To examine the
dynamics of this cell turnover, we transferred lymphocytic choriomeningitis virus specific …

The induction of immunological memory, which is mediated by memory T and B cells, is
central to adaptive protective immunity to pathogens induced by previous infection and is the …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …

The induction of long‐lived populations of memory T cells residing in peripheral tissues is of
considerable interest for T cell‐based vaccines, as they can execute immediate effector …

Highlights•Tissue resident memory T cells (T RM) are the main surveyors of non-lymphoid
tissues.•T RM activate innate and adaptive immunity and establish an antiviral state within …

Recent findings have revealed roles for systemic and mucosa-resident memory CD8+ T
cells in the orchestration of innate immune responses critical to host defense upon microbial …