The development and the differentiation of CD8+ T cells are dependent on IL‐15. Here, we
have studied the source and mechanism of how IL‐15 modulates CD8+ T cell‐mediated …

IL‐18 is a recently described cytokine that shares biological activities with IL‐12 in driving
the development of Th1‐type T cells. As dendritic cells (DC) are very potent inducers of T …

Dendritic cells (DC) can both initiate an immune response and dictate its character.
Cytokines are critically involved in this process and, although interleukin (IL)‐10 is known as …

Dendritic cells are the most relevant antigen‐presenting cells (APC) for presentation of
antigens administered in adjuvant to CD4+ T cells. Upon interaction with antigen‐specific T …

The identification of DC‐derived signals orchestrating activation of Th1 and Th17 immune
responses has advanced our understanding on how these inflammatory responses develop …

Interleukin (IL)‐7 is an essential nonredundant cytokine, and throughout the lifespan of a T‐
cell signaling via the IL‐7 receptor influences cell survival, proliferation and differentiation. It …

Abstract Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15.
They belong to a cytokine family that uses the common γ chain for signaling but also have …

Abstract IL-4 and IL-13 play key roles in Th2 immunity and asthma pathogenesis. Although
the function of these cytokines is partially linked through their shared use of IL-4Rα for …

In vivo evidence suggests that interleukin-18 (IL-18) shapes the development of adaptive
immunity toward T-helper cell type 1 (Th1) responses. Monocyte-derived dendritic cells 1 …

Abstract Interleukin (IL)‐4 is considered to be essential for T helper (Th) 2 cell development,
yet in areas of primary T cell activation, CD4+ cells are its only source. This implies that other …