In recent years, various intervention strategies have reduced malaria morbidity and mortality,
but further improvements probably depend upon development of a broadly protective …

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable
of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm …

Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following
a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive …

Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

Identification of correlates of protection for infectious diseases including malaria is a major
challenge and has become one of the main obstacles in developing effective vaccines. We …

Sterile immunity against live Plasmodium infection can be achieved by immunization with
radiation-attenuated sporozoites. This protection is known to be mediated in part by antigen …

Abstract Malaria results in> 1,000,000 deaths per year worldwide. Although no licensed
vaccine exists, much effort is currently focused on subunit vaccines that elicit CD8 T cell …

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected
cells and prevent malaria, but simple vaccines for generating this important immune …

Immunization with irradiated sporozoites is currently the most effective vaccination strategy
against liver stages of malaria parasites, yet the mechanisms underpinning the success of …

We previously demonstrated that protection induced by radiation-attenuated (γ) Plasmodium
berghei sporozoites is linked to MHC class I-restricted CD8+ T cells specific for …