Malaria is a major global health problem, with severe mortality in children living in sub-
Saharan Africa, and there is currently no licensed, effective vaccine. However, vaccine …

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been
used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria …

Nearly half of the world's population is at risk of malaria, a disease caused by the protozoan
parasite Plasmodium, which is estimated to cause more than 240,000,000 infections and kill …

Each year over 200 million malaria infections occur, with over 400 000 associated deaths.
Vaccines formed with attenuated whole parasites can induce protective memory CD8 T cell …

Abstract Malaria results in> 1,000,000 deaths per year worldwide. Although no licensed
vaccine exists, much effort is currently focused on subunit vaccines that elicit CD8 T cell …

Despite recent advances in treatment and vector control, malaria is still a leading cause of
death, emphasizing the need for an effective vaccine. The malaria life cycle can be …

Vaccination with a single dose of genetically attenuated malaria parasites can induce sterile
protection against sporozoite challenge in the rodent Plasmodium yoelii model. Protection is …

SUMMARY CD8+ T cells play a key role in protection against pre‐erythrocytic stages of
malaria infection. Many vaccine strategies are based on the idea of inducing a strong …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Despite decades of research, malaria remains a global health crisis. Current subunit vaccine
approaches do not provide efficient long-term, sterilizing immunity against Plasmodium …