Abstract Background Since 1986, investigators at Walter Reed Army Institute of Research
(WRAIR) have been using controlled human malaria challenge (CHMI) in malaria-naive …

Malaria remains the world's major parasitic infection, causing hundreds of millions of febrile
episodes and 1–2 million deaths annually—that is, 150–300 deaths occurring hourly day …

Abstract Controlled Human Malaria Infection (CHMI) is the most practiced controlled human
infection model nowadays and there is an exponential increase in implementation of the …

Programs for eradication of malaria have elimi-nated malaria from some areas of the world,
but in other areas where malaria persists, there is a continuing need for control measures …

The feasibility of using a sensitive polymerase chain reaction (PCR) to evaluate malaria
vaccines in small group sizes was tested in 102 adult Gambian volunteers who received …

Controlled human malaria infection (CHMI) is a powerful tool to evaluate the efficacy of
malaria vaccines and pharmacologics. Investigators at the University of Maryland, Baltimore …

Malaria draws global attention in a cyclic manner, with interest and associated financing
waxing and waning according to political and humanitarian concerns. Currently we are on …

Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

To explore the feasibility of field sites for malaria vaccine trials, we conducted a prospective
study of clinical malaria incidence during two consecutive transmission seasons in children …

Gains in the control of malaria and the promising progress of a malaria vaccine that is partly
efficacious do not reduce the need for a high-efficacy vaccine in the longer term. Evidence …