Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link between the
innate and adaptive immune systems. These cells are broadly involved in cellular and …

Dendritic cells (DCs) are involved in the initiation and regulation of innate and adaptive
immune responses. Several molecular mechanisms regulate these diverse DC functions …

Human dendritic cells (hDCs) produce IL-2 and express IL-2R α-chain (CD25), but the role
of IL-2 in DC functions is not well defined. A recent study suggested that the main function of …

IL-10 is a critical cytokine that blocks the maturation of dendritic cells (DCs), but the
relevance of autocrine IL-10 on DC functions has not been investigated. In this study, we …

IL-10 produced by dendritic cells (DC) can limit or terminate ongoing inflammatory
responses by inhibiting the proinflammatory cytokine production. Currently, the molecular …

Mice lacking IL-6 are resistant to autoimmune diseases, such as experimental autoimmune
encephalomyelitis (EAE), which is driven by CNS-reactive CD4+ T cells. There are multiple …

Dendritic cells (DC) not only stimulate T cells effectively but are also producers of cytokines
that have important immune regulatory functions. In this study we have extended information …

Interleukin-4 is a cytokine widely known for its role in CD4+ T cell polarization and its ability
to alternatively activate macrophage populations. In contrast, the impact of IL-4 on the …

Summary The interleukin-6 (IL-6) membrane receptor and its circulating soluble form, sIL-
6R, can be targeted by antibody therapy to reduce deleterious immune signaling caused by …

Dendritic cells (DCs) are key players in the development of immunity. They can direct both
the size and the quality of an immune response and thus are attractive tools to mediate …