[HTML][HTML] Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment

JJ Lee, R Wedow, A Okbay, E Kong, O Maghzian… - Nature …, 2018 - ncbi.nlm.nih.gov
We conduct a large-scale genetic association analysis of educational attainment in a sample
of~ 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs …

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

JJ Lee, R Wedow, A Okbay, E Kong, O Maghzian… - Nature …, 2018 - nature.com
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A Okbay, Y Wu, N Wang, H Jayashankar, M Bennett… - Nature …, 2022 - nature.com
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …

Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction

PA Demange, M Malanchini, TT Mallard, P Biroli… - Nature …, 2021 - nature.com
Little is known about the genetic architecture of traits affecting educational attainment other
than cognitive ability. We used genomic structural equation modeling and prior genome …

Genome-wide association study identifies 74 loci associated with educational attainment

A Okbay, JP Beauchamp, MA Fontana, JJ Lee, TH Pers… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

CA Rietveld, SE Medland, J Derringer, J Yang, T Esko… - science, 2013 - science.org
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Replicability and robustness of genome-wide-association studies for behavioral traits

CA Rietveld, D Conley, N Eriksson… - Psychological …, 2014 - journals.sagepub.com
A recent genome-wide-association study of educational attainment identified three single-
nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each …

Why genome-wide associations with cognitive ability measures are probably spurious

K Richardson, MC Jones - New Ideas in Psychology, 2019 - Elsevier
Much time and effort, as well as funding, is being devoted to Genome Wide Association
Studies (GWAS) for identifying genetic causes of variation (single nucleotide polymorphisms …

The genetics of success: How single-nucleotide polymorphisms associated with educational attainment relate to life-course development

DW Belsky, TE Moffitt, DL Corcoran… - Psychological …, 2016 - journals.sagepub.com
A previous genome-wide association study (GWAS) of more than 100,000 individuals
identified molecular-genetic predictors of educational attainment. We undertook in-depth life …

Polygenic influence on educational attainment: New evidence from the National Longitudinal Study of Adolescent to Adult Health

BW Domingue, DW Belsky, D Conley, KM Harris… - AERA …, 2015 - journals.sagepub.com
Recent studies have begun to uncover the genetic architecture of educational attainment.
We build on this work using genome-wide data from siblings in the National Longitudinal …