The omnigenic model was proposed as a framework to understand the highly polygenic
architecture of complex traits revealed by genome-wide association studies (GWASs). I …

Background The environment can moderate the effect of genes-a phenomenon called gene-
environment (GxE) interaction. Several studies have found that socioeconomic status (SES) …

The last decade of human genetic research witnessed the completion of hundreds of
genome-wide association studies (GWASs). However, the genetic variants discovered …

The last decade has seen the development of large‐scale genetics studies which have
advanced our understanding of the genetic architecture of many complex heritable traits. In …

The consequence of reduced cognitive ability from inbreeding has long been investigated,
mainly restricted to cousin–cousin marriages. Molecular genetic techniques now allow us to …

Genome‐wide association studies (GWAS) are a standard approach for investigating the
relationship of common variation within the human genome to a given phenotype of interest …

Intelligence, as measured by standardised tests of cognitive function, such as IQ-type tests,
is predictive of psychiatric diagnosis and psychological wellbeing. Using genome-wide …

The identification of multiple signals at individual loci could explain additional phenotypic
variance ('missing heritability') of common traits, and help identify causal genes. We …

Cognitive performance is highly heritable. However, little is known about common genetic
influences on cognitive ability and brain activation when engaged in a cognitive task. The …

Genome‐wide testing platforms are increasingly used to promote “agnostic” approaches to
the discovery of gene variants associated with the risk of many common diseases and …