Atherosclerosis as mitochondriopathy: repositioning the disease to help finding new therapies

T Shemiakova, E Ivanova, WK Wu… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a complex pathology that involves both metabolic dysfunction and chronic
inflammatory process. During the last decade, a considerable progress was achieved in …

Mitochondrial dysfunction: the hidden player in the pathogenesis of atherosclerosis?

G Ciccarelli, S Conte, G Cimmino, P Maiorano… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …

Mitochondrion as a selective target for the treatment of atherosclerosis: Role of mitochondrial DNA mutations and defective mitophagy in the pathogenesis of …

AN Orekhov, AV Poznyak, IA Sobenin… - Current …, 2020 - ingentaconnect.com
Background: Atherosclerosis is a chronic inflammatory condition that affects different arteries
in the human body and often leads to severe neurological complications, such as stroke and …

Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis

T Shemiakova, E Ivanova, AV Grechko, EV Gerasimova… - Biomedicines, 2020 - mdpi.com
Atherosclerosis is a multifactorial disease of the cardiovascular system associated with
aging, inflammation, and oxidative stress. An important role in the development of …

Disturbance of mitochondrial dynamics and mitochondrial therapies in atherosclerosis

AM Markin, VA Khotina, XG Zabudskaya, AI Bogatyreva… - Life, 2021 - mdpi.com
Mitochondrial dysfunction is associated with a wide range of chronic human disorders,
including atherosclerosis and diabetes mellitus. Mitochondria are dynamic organelles that …

[HTML][HTML] Effects of mitochondrial dysfunction on cellular function: Role in atherosclerosis

M Xu, W Wang, J Cheng, H Qu, M Xu… - Biomedicine & …, 2024 - Elsevier
Atherosclerosis, an immunoinflammatory disease of medium and large arteries, is
associated with life-threatening clinical events, such as acute coronary syndromes and …

[HTML][HTML] Mitochondria and cardiovascular diseases—from pathophysiology to treatment

G Siasos, V Tsigkou, M Kosmopoulos… - Annals of …, 2018 - ncbi.nlm.nih.gov
Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy

VM Victor, N Apostolova, R Herance… - Current medicinal …, 2009 - ingentaconnect.com
Chronic and acute overproduction of reactive oxygen species (ROS) under pathophysiologic
conditions forms an integral part of the development of cardiovascular diseases (CVD), and …

Mitochondria in vascular disease

E Yu, J Mercer, M Bennett - Cardiovascular research, 2012 - academic.oup.com
Mitochondria are often regarded as the powerhouse of the cell by generating the ultimate
energy transfer molecule, ATP, which is required for a multitude of cellular processes …

Mitochondrial dysfunction in vascular wall cells and its role in atherosclerosis

D Salnikova, V Orekhova, A Grechko… - International Journal of …, 2021 - mdpi.com
Altered mitochondrial function is currently recognized as an important factor in
atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by …