Several TLR ligands of bacterial origin induce innate immune responses. Although FimH,
the adhesin portion of type 1 fimbria, plays an important role in the pathogenicity of some …

Components of bacteria have been shown to induce innate antiviral immunity via Toll-like
receptors (TLRs). We have recently shown that FimH, the adhesin portion of type 1 fimbria …

The major and minor fimbriae proteins produced by the human pathogen Porphyromonas
gingivalis are required for invasion of human aortic endothelial cells and for the stimulation …

Although the importance of natural killer (NK) cells in innate immune responses against
tumors or viral infections are well documented, their ability to directly recognize pathogens is …

Fimbriae target bacteria to different mucosal surfaces and enhance the inflammatory
response at these sites. Inflammation may be triggered by the fimbriae themselves or by …

Fimbriae mediate bacterial attachment to host cells and provide a mechanism for tissue
attack. They activate a host response by delivery of microbial products such as …

Toll-like receptors (TLRs) are important signal transducers that mediate inflammatory
reactions induced by microbes through pattern recognition of virulence molecules such as …

The innate immune system precisely modulates the intensity of immune activation in
response to infection. Flagellin is a microbe-associated molecular pattern that is present on …

Type 1 fimbriae are proteinaceous filamentous structures present on bacterial surfaces and
are mainly composed of the major fimbrial protein subunit FimA and the adhesive protein …

TLRs trigger immunity by detecting microbe-associated molecular patterns (MAMPs).
Flagellin is a unique MAMP because it harbors 1) an antigenic hypervariable region and 2) …