Mitochondrial dysfunction in vascular wall cells and its role in atherosclerosis

D Salnikova, V Orekhova, A Grechko… - International Journal of …, 2021 - mdpi.com
Altered mitochondrial function is currently recognized as an important factor in
atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by …

Mitochondrial dysfunction: the hidden player in the pathogenesis of atherosclerosis?

G Ciccarelli, S Conte, G Cimmino, P Maiorano… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …

Mitochondrion as a selective target for the treatment of atherosclerosis: Role of mitochondrial DNA mutations and defective mitophagy in the pathogenesis of …

AN Orekhov, AV Poznyak, IA Sobenin… - Current …, 2020 - ingentaconnect.com
Background: Atherosclerosis is a chronic inflammatory condition that affects different arteries
in the human body and often leads to severe neurological complications, such as stroke and …

Atherosclerosis as mitochondriopathy: repositioning the disease to help finding new therapies

T Shemiakova, E Ivanova, WK Wu… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a complex pathology that involves both metabolic dysfunction and chronic
inflammatory process. During the last decade, a considerable progress was achieved in …

Mitochondrial mutations in atherosclerosis: new solutions in research and possible clinical applications

IA Sobenin, DA Chistiakov… - Current …, 2013 - ingentaconnect.com
Cardiovascular diseases are the leading causes of morbidity and mortality in many
industrialized societies. Atherosclerosis is the major risk factor for the development of …

Mutations of mitochondrial DNA in atherosclerosis and atherosclerosis-related diseases

IA Sobenin, AV Zhelankin… - Current …, 2015 - ingentaconnect.com
Atherosclerosis, the primary cause of cardiovascular disease, is a complex and multifactorial
pathology resulted from the harmful interactions between genetic and environmental factors …

The role of mitochondria in cardiovascular diseases

AV Poznyak, EA Ivanova, IA Sobenin, SF Yet… - Biology, 2020 - mdpi.com
The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a
central player in the regulation of cellular metabolism and a powerful controller of cellular …

Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis

T Shemiakova, E Ivanova, AV Grechko, EV Gerasimova… - Biomedicines, 2020 - mdpi.com
Atherosclerosis is a multifactorial disease of the cardiovascular system associated with
aging, inflammation, and oxidative stress. An important role in the development of …

Changes in mitochondrial genome associated with predisposition to atherosclerosis and related disease

A Volobueva, A Grechko, SF Yet, I Sobenin, A Orekhov - Biomolecules, 2019 - mdpi.com
Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and
mortality, and the search for novel diagnostic and therapeutic methods is ongoing …

[HTML][HTML] Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes

DA Chistiakov, IA Sobenin, YV Bobryshev… - World journal of …, 2012 - ncbi.nlm.nih.gov
Mitochondrial DNA (mtDNA) is particularly prone to oxidation due to the lack of histones and
a deficient mismatch repair system. This explains an increased mutation rate of mtDNA that …