Natural parasite exposure induces protective human anti-malarial antibodies
G Triller, SW Scally, G Costa, M Pissarev, C Kreschel… - Immunity, 2017 - cell.com
Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface
antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal …
antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal …
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs
The circumsporozoite protein of the human malaria parasite Plasmodium falciparum
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …
(PfCSP) is the main target of antibodies that prevent the infection and disease, as shown in …
Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes
Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum
circumsporozoite protein (CSP Repeat) can protect against malaria. However, it has also …
circumsporozoite protein (CSP Repeat) can protect against malaria. However, it has also …
A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver
LT Wang, LS Pereira, Y Flores-Garcia, J O'Connor… - Immunity, 2020 - cell.com
Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies
Repeat antigens, such as the Plasmodium falciparum circumsporozoite protein (PfCSP), use
both sequence degeneracy and structural diversity to evade the immune response. A few …
both sequence degeneracy and structural diversity to evade the immune response. A few …
Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein
Acquired resistance against antimalarial drugs has further increased the need for an
effective malaria vaccine. The current leading candidate, RTS, S, is a recombinant …
effective malaria vaccine. The current leading candidate, RTS, S, is a recombinant …
Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection
The generation of high-quality antibody responses to Plasmodium falciparum (Pf)
circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is …
circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is …
A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
Potent and durable vaccine responses will be required for control of malaria caused by
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection
Antibodies against the central repeat of the Plasmodium falciparum (Pf) circumsporozoite
protein (CSP) inhibit parasite activity and correlate with protection from malaria. However …
protein (CSP) inhibit parasite activity and correlate with protection from malaria. However …
T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein
CR Fisher, HJ Sutton, JA Kaczmarski… - PLoS …, 2017 - journals.plos.org
The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major
vaccine antigen because it can be targeted by parasite neutralizing antibodies; however …
vaccine antigen because it can be targeted by parasite neutralizing antibodies; however …