[HTML][HTML] Possible role of mitochondrial DNA mutations in chronification of inflammation: focus on atherosclerosis

AN Orekhov, NN Nikiforov, EA Ivanova… - Journal of clinical …, 2020 - mdpi.com
Chronification of inflammation is the process that lies at the basis of several human diseases
that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of …

[HTML][HTML] The role of mitochondrial mutations in chronification of inflammation: hypothesis and overview of own data

AN Orekhov, NG Nikiforov, AV Omelchenko, VV Sinyov… - Life, 2022 - mdpi.com
Chronic human diseases, especially age-related disorders, are often associated with
chronic inflammation. It is currently not entirely clear what factors are responsible for the …

Mitochondrial DNA and inflammatory diseases

G Escames, LC López, JA García, L Garcia-Corzo… - Human genetics, 2012 - Springer
Increasing experimental evidence supports a connection between inflammation and
mitochondrial dysfunction. Both acute and chronic inflammatory diseases course with …

[HTML][HTML] Mitochondrial dysfunction in vascular wall cells and its role in atherosclerosis

D Salnikova, V Orekhova, A Grechko… - International Journal of …, 2021 - mdpi.com
Altered mitochondrial function is currently recognized as an important factor in
atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by …

Susceptibility of monocytes to activation correlates with atherogenic mitochondrial DNA mutations

AN Orekhov, AV Zhelankin, KI Kolmychkova… - Experimental and …, 2015 - Elsevier
We have recently evaluated the susceptibility of circulating monocytes to pro-and anti-
inflammatory activation comparing samples from healthy individuals and patients with …

Mitochondrion as a selective target for the treatment of atherosclerosis: Role of mitochondrial DNA mutations and defective mitophagy in the pathogenesis of …

AN Orekhov, AV Poznyak, IA Sobenin… - Current …, 2020 - ingentaconnect.com
Background: Atherosclerosis is a chronic inflammatory condition that affects different arteries
in the human body and often leads to severe neurological complications, such as stroke and …

[HTML][HTML] From mitochondria to atherosclerosis: the inflammation path

JM Suárez-Rivero, CJ Pastor-Maldonado… - Biomedicines, 2021 - mdpi.com
Inflammation is a key process in metazoan organisms due to its relevance for innate defense
against infections and tissue damage. However, inflammation is also implicated in …

[HTML][HTML] Atherosclerosis as mitochondriopathy: repositioning the disease to help finding new therapies

T Shemiakova, E Ivanova, WK Wu… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a complex pathology that involves both metabolic dysfunction and chronic
inflammatory process. During the last decade, a considerable progress was achieved in …

[HTML][HTML] The role of mitochondria in cardiovascular diseases related to atherosclerosis

VY Glanz, IA Sobenin, AV Grechko, SF Yet… - Frontiers in Bioscience …, 2020 - imrpress.com
Atherosclerosis is a complex disorder that involves several mechanisms of pathogenesis
tightly related to each other: lipid accumulation, inflammation and structural changes in the …

[HTML][HTML] Mitochondrial dysfunction: the hidden player in the pathogenesis of atherosclerosis?

G Ciccarelli, S Conte, G Cimmino, P Maiorano… - International Journal of …, 2023 - mdpi.com
Atherosclerosis is a multifactorial inflammatory pathology that involves metabolic processes.
Improvements in therapy have drastically reduced the prognosis of cardiovascular disease …