Transmission-blocking vaccines: harnessing herd immunity for malaria elimination
PE Duffy - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction Transmission-blocking vaccines (TBV) prevent community spread of malaria by
targeting mosquito sexual stage parasites, a life-cycle bottleneck, and will be used in …
targeting mosquito sexual stage parasites, a life-cycle bottleneck, and will be used in …
Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine
KA Collins, R Snaith, MG Cottingham, SC Gilbert… - Scientific reports, 2017 - nature.com
The leading malaria vaccine in development is the circumsporozoite protein (CSP)-based
particle vaccine, RTS, S, which targets the pre-erythrocytic stage of Plasmodium falciparum …
particle vaccine, RTS, S, which targets the pre-erythrocytic stage of Plasmodium falciparum …
Malaria vaccines: recent advances and new horizons
The development of highly effective and durable vaccines against the human malaria
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor …
IgG2 Antibodies against a Clinical Grade Plasmodium falciparum CSP Vaccine Antigen Associate with Protection against Transgenic Sporozoite Challenge in Mice
R Schwenk, M DeBot, M Porter, J Nikki, L Rein… - PloS one, 2014 - journals.plos.org
The availability of a highly purified and well characterized circumsporozoite protein (CSP) is
essential to improve upon the partial success of recombinant CSP-based malaria vaccine …
essential to improve upon the partial success of recombinant CSP-based malaria vaccine …
Progress and prospects for blood-stage malaria vaccines
K Miura - Expert review of vaccines, 2016 - Taylor & Francis
There have been significant decreases in malaria mortality and morbidity in the last 10-15
years, and the most advanced pre-erythrocytic malaria vaccine, RTS, S, received a positive …
years, and the most advanced pre-erythrocytic malaria vaccine, RTS, S, received a positive …
Pre-erythrocytic malaria vaccines: identifying the targets
Pre-erythrocytic malaria vaccines target Plasmodium during its sporozoite and liver stages,
and can prevent progression to blood-stage disease, which causes a million deaths each …
and can prevent progression to blood-stage disease, which causes a million deaths each …
Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS, S/AS01E malaria vaccine efficacy
Abstract RTS, S/AS01E has been tested in a phase 3 malaria vaccine study with partial
efficacy in African children and infants. In a cohort of 1028 subjects from one low …
efficacy in African children and infants. In a cohort of 1028 subjects from one low …
The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection
Vaccination with the pre-erythrocytic malaria vaccine RTS, S induces high levels of
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …
Insights into long-lasting protection induced by RTS, S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children
C Guinovart, JJ Aponte, J Sacarlal, P Aide, A Leach… - PLoS …, 2009 - journals.plos.org
Background The pre-erythrocytic malaria vaccine RTS, S/AS02A has shown to confer
protection against clinical malaria for at least 21 months in a trial in Mozambican children …
protection against clinical malaria for at least 21 months in a trial in Mozambican children …
[HTML][HTML] Designing malaria vaccines to circumvent antigen variability
Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but
parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent …
parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent …