Spatiotemporal immunomodulation using biomimetic scaffold promotes endochondral ossification‐mediated bone healing

Y Liu, Z Yang, L Wang, L Sun, BYS Kim… - Advanced …, 2021 - Wiley Online Library
Biomaterials play an important role in treating bone defects by promoting direct osteogenic
healing through intramembranous ossification (IO). However, majority of the body's bones …

Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages

D Henn, K Chen, T Fehlmann, AA Trotsyuk… - Science …, 2021 - science.org
Skin allo-and xenotransplantation are the standard treatment for major burns when donor
sites for autografts are not available. The relationship between the immune response to …

Ligand‐selective targeting of macrophage hydrogel elicits bone immune‐stem cell endogenous self‐healing program to promote bone regeneration

J Wang, L Zhang, L Wang, J Tang… - Advanced …, 2024 - Wiley Online Library
Targeting macrophages can facilitate the site‐specific repair of critical bone defects. Herein,
a composite hydrogel, gelatin‐Bletilla striata polysaccharide‐mesoporous bioactive glass …

A xenogeneic extracellular matrix-based 3D printing scaffold modified by ceria nanoparticles for craniomaxillofacial hard tissue regeneration via osteo …

J Chen, Y Huang, H Tang, X Qiao, X Sima… - Biomedical …, 2024 - iopscience.iop.org
Hard tissue engineering scaffolds especially 3D printed scaffolds were considered an
excellent strategy for craniomaxillofacial hard tissue regeneration, involving crania and …

Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine

M Kasravi, A Ahmadi, A Babajani… - Biomaterials …, 2023 - spj.science.org
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to
address the donor shortage as well as immunologic rejection attributed to cells in …

Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

L Du, J Wu, Y Han, C Wu - Science Advances, 2024 - science.org
Limited motor activity due to the loss of natural structure impedes recovery in patients
suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the …

M2 Macrophage Hybrid Membrane‐Camouflaged Targeted Biomimetic Nanosomes to Reprogram Inflammatory Microenvironment for Enhanced Enzyme‐Thermo …

R Chen, J Yang, M Wu, D Zhao, Z Yuan… - Advanced …, 2023 - Wiley Online Library
Excessive inflammatory reactions caused by uric acid deposition are the key factor leading
to gout. However, clinical medications cannot simultaneously remove uric acid and eliminate …

LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

D Ti, H Hao, C Tong, J Liu, L Dong, J Zheng… - Journal of translational …, 2015 - Springer
Background Within the last few years, it has become evident that LPS-preconditioned
mesenchymal stromal cells (LPS pre-MSCs) show enhanced paracrine effects, including …

Biomimic Trained Immunity‐MSCs Delivery Microcarriers for Acute Liver Failure Regeneration

J Wang, D Huang, H Ren, L Shang - Small, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have a demonstrated value for acute liver failure (ALF)
regeneration, while their delivery stratagems with long‐term biological functions, low …

Decellularized matrices as cell-instructive scaffolds to guide tissue-specific regeneration

KP Robb, A Shridhar, LE Flynn - ACS Biomaterials science & …, 2017 - ACS Publications
Decellularized scaffolds are promising clinically translational biomaterials that can be
applied to direct cell responses and promote tissue regeneration. Bioscaffolds derived from …