Introduction Tolerogenic Dendritic Cells (tolDCs) have an exceptional promise as a potential
therapy for autoimmune disease and transplantation rejection. TolDCs are a unique …

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate
and adaptive immune responses, thereby leading to immune activation. DCs have been …

Tolerogenic dendritic cells (tolDCs) have reached patients with autoimmune and
inflammatory disease, at least in clinical trials. The safety of tolDCs as intervention therapy …

Background Generation of tolerogenic dendritic cells (TolDCs) for therapy is challenging
due to its implications for the design of protocols suitable for clinical applications, which …

Dendritic cells (DCs) play a key role not only in the initiation of primary immune responses,
but also in the development and maintenance of immune tolerance. Numerous protocols …

Tolerogenic dendritic cells (TolDCs) are actively involved in the elimination of autoreactive T
cells in the thymus and quench T cell responses to self-antigens in the periphery under …

The immune system operates by maintaining a tight balance between coordinating
responses against foreign antigens and maintaining an unresponsive state against self …

Dendritic cells (DCs) dictate the outcomes of tissue-specific immune responses. In the
context of autoimmune diseases, DCs instruct T cells to respond to antigens (Ags), including …

Autoimmune diseases affect about one in 15 individuals in developed countries and are
characterized by a breakdown in immune tolerance. Current therapeutic approaches against …

A failure of central immune tolerance driven by autoantigen specific T regulatory (Treg) cells
is a major cause of many autoimmune diseases. Restoration of proper autoantigen Treg …