Bone targeting is one of the most potentially valuable therapeutic methods for medically
treating bone diseases, such as osteoarthritis, osteoporosis, nonunion bone defects, bone …

In this paper, we synthesized a range of amphiphilic Janus dendrimers, which consisted of
acidic amino acid and naproxen molecules as the peripheral groups, as novel potential …

Bone-drug targeting therapies using nanoparticles based on targeting ligands remain
challenging due to their uptake clearance at non-target sites such as the liver, kidney, and …

In this study, we aimed to develop a polyethylene glycol (PEG)-conjugated third generation
polyamidoamine (PAMAM) dendrimer with multiple carboxylic acids as a bone-targeting …

We developed a bone-targeting dendrimer for the delivery of anti-tumour agents and
effective treatment of bone metastasis, in which alendronate (ALN), a bone-targeting moiety …

To considerably enhance treatment efficacy for bone metastatic breast cancer via dual
bone/tumor-targeted chemotherapy, a nanoparticle-based delivery system comprising poly …

Osteoporosis represents a major public health burden especially considering the aging
population worldwide. Treatment modalities for osteoporosis are classified into two …

Tumor bone metastasis is an important cause of tumor recurrence and death. Although bone-
targeting nanoparticles decorated with targeting ligands have shown good affinity for bone …

Bortezomib is a boronate proteasome inhibitor widely used as an efficient anticancer drug;
however, the clinical use of bortezomib is hampered by its adverse effects such as …

To improve bone metastasis chemotherapy, a peptide-conjugated diblock copolymer
consisting of a chimeric peptide, poly (ethylene glycol) and poly (trimethylene …