Polygenic risk scores for the prediction of cardiometabolic disease
Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
Current state and future of polygenic risk scores in cardiometabolic disease: a scoping review
A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …
Polygenic risk score: clinically useful tool for prediction of cardiovascular disease and benefit from lipid-lowering therapy?
N Arnold, W Koenig - Cardiovascular Drugs and Therapy, 2021 - Springer
Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using
information on the genetic predisposition at an individual level might offer new possibilities …
information on the genetic predisposition at an individual level might offer new possibilities …
Interactions between enhanced polygenic risk scores and lifestyle for cardiovascular disease, diabetes, and lipid levels
Background: Both lifestyle and genetic factors confer risk for cardiovascular diseases, type 2
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …
Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses
Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …
Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later
Background Several polygenic risk scores (PRS) have been developed for cardiovascular
risk prediction, but the additive value of including PRS together with conventional risk factors …
risk prediction, but the additive value of including PRS together with conventional risk factors …
How do we incorporate polygenic risk scores in cardiovascular disease risk assessment and management?
TD Hadley, AM Agha, CM Ballantyne - Current atherosclerosis reports, 2021 - Springer
Abstract Purpose of Review The potential of polygenic risk scores (PRS) to improve
atherosclerotic cardiovascular disease (ASCVD) risk assessment and management has …
atherosclerotic cardiovascular disease (ASCVD) risk assessment and management has …
Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
Polygenic risk scores for cardiovascular diseases and type 2 diabetes
Polygenic risk scores (PRSs) are a promising approach to accurately predict an individual's
risk of developing disease. The area under the receiver operating characteristic curve (AUC) …
risk of developing disease. The area under the receiver operating characteristic curve (AUC) …
Polygenic risk scores and coronary artery disease: ready for prime time?
MG Levin, DJ Rader - Circulation, 2020 - Am Heart Assoc
Polygenic risk scores represent a method of aggregating an individual's genetic information,
weighted by associations between genetic variants and disease outcomes identified from …
weighted by associations between genetic variants and disease outcomes identified from …