The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague
the globe. The SARS-CoV-2 main protease, or M pro, is a promising target for development …

The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague
the globe. The SARS-CoV-2 main protease, or Mpro, is a promising target for the …

The SARS-CoV-2 main protease (M pro) is essential to viral replication and cleaves highly
specific substrate sequences, making it an obvious target for inhibitor design. However, as …

The COVID19 pandemic has resulted in 25+ million reported infections and nearly 850.000
deaths. Research to identify effective therapies for COVID19 includes: i) designing a vaccine …

The COVID-19 pandemic has resulted in 198 million reported infections and more than 4
million deaths as of July 2021 (covid19. who. int). Research to identify effective therapies for …

Coronaviruses can evolve and spread rapidly to cause severe disease morbidity and
mortality, as exemplified by SARS-CoV-2 variants of the COVID-19 pandemic. Although …

The emergence of new SARS-CoV-2 variants has raised concerns about the effectiveness of
COVID-19 vaccines. To address this challenge, small-molecule antivirals have been …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency …

The COVID-19 pandemic is a stark reminder that a barren global antiviral pipeline has grave
humanitarian consequences. Future pandemics could be prevented by accessible, easily …

The recent pandemic outbreak of COVID-19, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), raised global health and economic concerns …