Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

Meiotic spindle assembly ensures proper chromosome segregation in oocytes. However,
the mechanisms behind spindle assembly in human oocytes remain largely unknown. We …

INTRODUCTION When an egg is fertilized by a sperm, the chromosomes of the mother and
the father become united, and a genetically unique embryo starts to form. A healthy embryo …

INTRODUCTION Mammalian embryos frequently develop abnormally, resulting in
miscarriages and genetic disorders such as Down syndrome. The major cause for aberrant …

Aneuploidy in human eggs is the leading cause of pregnancy loss and several genetic
disorders such as Down syndrome. Most aneuploidy results from chromosome segregation …

Human eggs frequently contain an incorrect number of chromosomes, a condition termed
aneuploidy. Aneuploidy affects∼ 10–25% of eggs in women in their early 30s, and more …

Mammalian oocytes assemble a bipolar acentriolar microtubule spindle to segregate
chromosomes during asymmetric division. There is increasing evidence that actin in the …

Chromosome segregation in mammalian oocytes is driven by a microtubule spindle lacking
centrosomes. Here, we analyze centrosome-independent spindle assembly by quantitative …

An oocyte matures into an egg by extruding half of the chromosomes in a small polar body.
This extremely asymmetric division enables the oocyte to retain sufficient storage material …

Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual
cycle, an oocyte matures into a fertilizable egg in the ovary. To this end, the oocyte …