Preventing antimalarial drug resistance with triple artemisinin-based combination therapies

TD Nguyen, B Gao, C Amaratunga, M Dhorda… - Nature …, 2023 - nature.com
Increasing levels of artemisinin and partner drug resistance threaten malaria control and
elimination globally. Triple artemisinin-based combination therapies (TACTs) which …

Emerging artemisinin resistance in the border areas of Thailand

K Na-Bangchang, J Karbwang - Expert review of clinical …, 2013 - Taylor & Francis
Emergence of artemisinin resistance has been confirmed in Cambodia and the border areas
of Thailand, the well-known hotspots of multidrug resistance Plasmodium falciparum. It …

How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance

I Hastings - Trends in parasitology, 2011 - cell.com
Antimalarial drug therapies containing artemisinins,'ACTs', have become the mainstay for
treating uncomplicated malaria in endemic countries. This is a major public health …

High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure

RK Tyagi, PJ Gleeson, L Arnold, R Tahar, E Prieur… - BMC medicine, 2018 - Springer
Background Humanity has become largely dependent on artemisinin derivatives for both the
treatment and control of malaria, with few alternatives available. A Plasmodium falciparum …

[HTML][HTML] Artemisinin resistance: An important emerging clinical problem in tropical medicine

S Yasri, V Wiwanitkit - International Journal of Physiology …, 2021 - ncbi.nlm.nih.gov
Artemisinin is an important antimalarial drug which is originated and developed from
Chinese traditional herbal regimen. At present, artemisinin is used as an antimalarial drug …

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

Artemisinin resistance: how can we find it?

H Noedl - Trends in parasitology, 2005 - cell.com
Since 2001, 40 countries have officially adopted artemisininbased combination therapy for
treating Plasmodium falciparum malaria [1]. Of these countries, 20 have adopted the …

Malaria medicines to address drug resistance and support malaria elimination efforts

J Achan, J Mwesigwa, CP Edwin… - Expert review of clinical …, 2018 - Taylor & Francis
Introduction: Antimalarial drugs are essential weapons to fight malaria and have been used
effectively since the 17th century. However, P. falciparum resistance has been reported to …

The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

T Masserey, T Lee, M Golumbeanu, AJ Shattock… - Elife, 2022 - elifesciences.org
The effectiveness of artemisinin-based combination therapies (ACTs) to treat Plasmodium
falciparum malaria is threatened by resistance. The complex interplay between sources of …

Artemisinins: artemisinin, dihydroartemisinin, artemether and artesunate

HA Karunajeewa - Treatment and prevention of malaria: antimalarial drug …, 2012 - Springer
Artemisinin comes from the plant, Artemisia annua, an ancient Chinese herbal remedy for
relapsing fever. Rediscovery of its antimalarial action in China in the 1970s has seen it and …