The drug resistance specter looms over most infectious diseases. Malaria provides a
particularly urgent example of increasing resistance and treatment failure. In the past …

Parasite resistance to conventional antimalarial medicines has led, in recent years, to a
dramatic shift in malaria treatment. Sixty-seven countries with endemic Plasmodium …

Artemisinins are the most rapidly acting of currently available antimalarial drugs. Artesunate
has become the treatment of choice for severe malaria, and artemisinin-based combination …

Antimalarial drug resistance is a major public health challenge and the principal reason for
the erosion of efficacious treatments. Cost and the limited number of antimalarial drugs in …

Artemisinin-based combination therapies (ACTs) are the cornerstone of current strategies for
fighting malaria. Over the last decade, ACTs have played a major role in decreasing malaria …

Background The emergence of artemisinin resistance has raised concerns that the most
potent antimalarial drug may be under threat. The currently recommended daily dose of …

Plasmodium falciparum, the causative agent of malaria, has been developing resistance to
several drugs worldwide for more than five decades. Initially, resistance was against drugs …

Artemisinin (ART) based combination therapy (ACT) is used as the first line treatment of
uncomplicated falciparum malaria in over 100 countries and is the cornerstone of malaria …

Malaria, a disease transmitted by the female Anopheles mosquito, has had devastating
effects on human populations for more than 4000 years. Treatment of the disease with single …

The global challenge to the treatment of malaria is mainly the occurrence of resistance of
malaria parasites to conventionally used antimalarials. Artesunate, a semisynthetic …