The existing armamentarium of drugs for the treatment and prevention of malaria is limited
primarily by resistance (and cross-resistance between closely related drugs). However, most …

Background Artemisinin-based combination therapies are the recommended first-line
treatments of falciparum malaria in all countries with endemic disease. There are recent …

Covering: Up to 2020 Artemisinin has made a significant contribution towards global malaria
control since its initial discovery. Countless lives have been saved by this unique and …

Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

Managing multidrug resistant malaria can be problematic if currently available artemisinin-
containing anti-malarial combination treatments are not used appropriately. Here, I debate …

Should ACTs fail, no suitable alternatives exist as first-line treatments of P. falciparum
malaria. Intensified efforts are essential to monitor the spread of resistance, define …

Background Artemisinin resistance is threatening malaria control. We aimed to develop and
test a human model of artemisinin-resistant (ART-R) Plasmodium falciparum to evaluate the …

Over the past six decades, the drug resistance of Plasmodium falciparum has become an
issue of utmost concern. Despite the remarkable progress that has been made in recent …

Objective Recent reports indicate that first cases of genuine artemisinin resistance have
already emerged along the Thai-Cambodian border. The main objective of this trial was to …

Malaria represents one of the most serious threats to human health worldwide, and
preventing and curing this parasitic disease still depends predominantly on the …