Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

The emergence of artemisinin resistance is a major obstacle to the global malaria
eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is …

Despite international efforts to 'roll back malaria'the 2008 World Malaria Report revealed the
disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …

Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …

Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …

Artemisinin and its derivatives represent the most important and influential class of drugs in
the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global …

The definition of artemisinin resistance is becoming one of a prolonged parasite clearance
phenotype, although this variable is a complex function of both host and parasite …

The artemisinins are the most effective antimalarial drugs known. They possess a
remarkably wide therapeutic index. These agents have been used in traditional Chinese …

Parasite resistance to conventional antimalarial medicines has led, in recent years, to a
dramatic shift in malaria treatment. Sixty-seven countries with endemic Plasmodium …

Increasing levels of artemisinin and partner drug resistance threaten malaria control and
elimination globally. Triple artemisinin-based combination therapies (TACTs) which …