Abstract Acquired Immuno Defficiency Syndrome (AIDS) is one of the major global life
threatening condition caused by Human Immunodeficiency Virus (HIV) and its prevalence …

Discovering novel NDM-1 inhibitors is an urgent task for treatment of 'superbug'infectious
diseases. In this study, we found that naturally occurring houttuynin and its sulfonate …

Abstract β-lactams are large group of antibiotics widely used to suppress the bacterial
growth by inhibiting cell wall synthesis. Bacterial resistance against β-lactam antibiotics is …

Abstract New Delhi-β-lactamase-1 (NDM-1) is a type of one of metal-β-lactamase. NDM-1-
expressing bacteria can rapidly spread globally through plasmid transfer, greatly …

Over the past few decades, various inhibitors of PRMT5 have been developed because of its
involvement in a variety of tumor development processes. As of now, no drugs targeting …

Abstract Matrix metal proteinases-12 (MMP-12) is a hot pharmaceutical target on the
treatment of many human diseases. There'sa crying need for designing and finding new …

Tuberculosis is a chronic communicable disease caused by Mycobacterium tuberculosis
(Mtb) and spreads from lungs to lymphatic system. The cell wall of mycobacterium plays a …

DNA methyl transferases (DNMTs) are one of the crucial epigenetic modulators associated
with a wide variety of cancer conditions. Among the DNMT isoforms, DNMT1 is correlated …

Bacterial resistance is undoubtedly one of the main public health concerns especially with
the emergence of metallo-β-lactamases (MBLs) able to hydrolytically inactivate β-lactam …