Various antiretroviral drugs do not kill or cure the human immunodeficiency virus (HIV) but
do prevent the replication of the virus. The combination of antiretroviral drugs is known as …

The development of antiretroviral therapy (ART) has been effective in suppressing HIV
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …

The major barrier to eradication of HIV infection is the latent viral reservoir that persists
despite long-term highly active antiretroviral therapy (HAART). The main reason for the …

The HIV‐1 virus (human immunodeficiency virus) affects 36.9 million people worldwide, with
approximately 900000 deaths in 2017. The virus carrier can develop severe …

The research community has been captivated by CRISPR/Cas9's many potential health
applications; new findings suggest that this system may eventually be used to combat HIV …

CRISPR/Cas9 is an adaptive immune system where bacteria and archaea have evolved to
resist the invading viruses and plasmid DNA by creating site-specific double-strand breaks …

Introduction: The use of antiretroviral therapy has led to a significant decrease in morbidity
and mortality in HIV-infected individuals. Nevertheless, gene-based therapies represent a …

Abstract Background The novel endonuclease Cas12b was engineered for targeted
genome editing in mammalian cells and is a promising tool for certain applications because …

Gene editing approaches using CRISPR/Cas9 are being developed as a means for
targeting the integrated HIV-1 provirus. Enthusiasm for the use of gene editing as an anti …

Highlights•HIV provirus in infected cells can be inactivated with CRISPR–
Cas9.•Combinatorial CRISPR–Cas9 attack can prevent viral escape.•Both mutation and …