An overview of novel adjuvants designed for improving vaccine efficacy

SR Bonam, CD Partidos, SKM Halmuthur… - Trends in pharmacological …, 2017 - cell.com
Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact
vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In …

Immunological concepts of vaccine adjuvant activity: Commentary

VEJC Schijns - Current opinion in immunology, 2000 - Elsevier
The successful elimination of pathogens following prophylactic immunization depends to a
large extent on the ability of the host's immune system to recognize when it is necessary to …

[图书][B] Vaccine adjuvants: preparation methods and research protocols

DT O'Hagan - 2008 - books.google.com
Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly
describe the preparation, characterization, and evaluation of a wide range of alternative …

[HTML][HTML] Using adjuvants to drive T cell responses for next-generation infectious disease vaccines

RR Rapaka, AS Cross, MA McArthur - Vaccines, 2021 - mdpi.com
Using adjuvants to drive features of T cell responses to vaccine antigens is an important
technological challenge in the design of new and improved vaccines against infections …

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

V Schijns, A Fernández‐Tejada… - Immunological …, 2020 - Wiley Online Library
Therapeutic vaccination offers great promise as an intervention for a diversity of infectious
and non‐infectious conditions. Given that most chronic health conditions are thought to have …

Improving vaccine delivery using novel adjuvant systems

ME Pichichero - Human vaccines, 2008 - Taylor & Francis
Adjuvants have been common additions to vaccines to help facilitate vaccine delivery. With
advancements in vaccine technology, several adjuvants which activate immune specific …

[HTML][HTML] New-age vaccine adjuvants, their development, and future perspective

SK Verma, P Mahajan, NK Singh, A Gupta… - Frontiers in …, 2023 - frontiersin.org
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …

[HTML][HTML] Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

NPH Knudsen, A Olsen, C Buonsanti, F Follmann… - Scientific reports, 2016 - nature.com
The majority of vaccine candidates in clinical development are highly purified proteins and
peptides relying on adjuvants to enhance and/or direct immune responses. Despite the …

Immunomodulators as adjuvants for vaccines and antimicrobial therapy

EF Nicholls, L Madera… - Annals of the New York …, 2010 - Wiley Online Library
A highly effective strategy for combating infectious diseases is to enhance host defenses
using immunomodulators, either preventatively, through vaccination, or therapeutically. The …

[HTML][HTML] Mechanisms of action of adjuvants

S Awate, LA Babiuk, G Mutwiri - Frontiers in immunology, 2013 - frontiersin.org
Adjuvants are used in many vaccines, but their mechanisms of action are not fully
understood. Studies from the past decade on adjuvant mechanisms are slowly revealing the …