The ease of breeding, low cost of maintenance, and relatively short period for developing
atherosclerosis make rodents ideal for atherosclerosis research. However, none of the …

Laboratory animal models play an important role in the study of human diseases. Using
appropriate animals is critical not only for basic research but also for the development of …

In this mini-review several commonly used animal models of atherosclerosis have been
discussed. Among them, emphasis has been made on mice, rabbits, pigs and non-human …

An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

Background and aims Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe)
knockout (KO) mice have been widely used as animal models of atherosclerosis. However …

Atherosclerosis is a leading cause of death worldwide, and its mechanisms are still unclear.
However, various animal models have significantly advanced our understanding of the …

Atherosclerosis represents a significant cause of morbidity and mortality in both the
developed and developing countries. Animal models of atherosclerosis have served as …

The mouse has been used as an experimental model for atherosclerosis research for only a
short time; however, the sophisticated genetics of this species has resulted in a number of …

Atherosclerosis is a complex disease in which progressive cellular changes occur for
decades before the acute manifestation of cardiovascular disease. Definition of atherogenic …

Atherosclerosis retains the leading position among the causes of global morbidity and
mortality worldwide, especially in the industrialized countries. Despite the continuing efforts …