The state of the dopaminergic and glutamatergic systems in the valproic acid mouse model of autism spectrum disorder

A Maisterrena, E Matas, H Mirfendereski, A Balbous… - Biomolecules, 2022 - mdpi.com
Autism Spectrum Disorder (ASD) is a progressive neurodevelopmental disorder mainly
characterized by deficits in social communication and stereotyped behaviors and interests …

Early cellular and synaptic changes in dopaminoceptive forebrain regions of juvenile mice following gestational exposure to valproate

CK Finszter, R Kemecsei, G Zachar… - Frontiers in …, 2023 - frontiersin.org
Gestational exposure of mice to valproic acid (VPA) is one currently used experimental
model for the investigation of typical failure symptoms associated with autism spectrum …

Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: A screening test

J Lenart, J Augustyniak, JW Lazarewicz, E Zieminska - Toxicology, 2020 - Elsevier
Autism spectrum disorders (ASD) include neurodevelopmental disorders in which
behavioral deficits can result from neuronal imbalance of excitation to inhibition (E/I) in the …

Male‐specific alteration in excitatory post‐synaptic development and social interaction in pre‐natal valproic acid exposure model of autism spectrum disorder

KC Kim, P Kim, HS Go, CS Choi, JH Park… - Journal of …, 2013 - Wiley Online Library
Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by
three main behavioral symptoms including social deficits, impaired communication, and …

Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid

N Kazlauskas, M Campolongo, L Lucchina… - …, 2016 - Elsevier
Abstract In Autism Spectrum Disorders (ASD), a bias to a higher incidence in boys than in
girls has been reported. With the aim to identify biological mechanisms acting in female …

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

Y Hara, K Takuma, E Takano, K Katashiba… - Behavioural brain …, 2015 - Elsevier
Previous studies suggest that dysfunction of neurotransmitter systems is associated with the
pathology of autism in humans and the disease model rodents, but the precise mechanism …

Molecular pathology and pharmacological treatment of autism spectrum disorder-like phenotypes using rodent models

HY Kuo, FC Liu - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder with a
high prevalence rate. The core symptoms of ASD patients are impaired social …

Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages

Y Kasahara, C Yoshida, K Nakanishi, M Fukase… - Scientific Reports, 2020 - nature.com
Autism spectrum disorder (ASD) is characterized by impairment of social communication,
repetitive behavior and restrictive interest. The risk of ASD is strongly associated with the …

Neuroimmune alterations in autism: a translational analysis focusing on the animal model of autism induced by prenatal exposure to valproic acid

I Deckmann, GB Schwingel, M Fontes-Dutra… - …, 2019 - karger.com
Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized
by deficits in communication and social interaction and in stereotyped or repetitive …

Pathophysiological studies of monoaminergic neurotransmission systems in valproic acid-induced model of autism spectrum disorder

HY Kuo, FC Liu - Biomedicines, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology.
The core syndromes of ASD are deficits in social communication and self-restricted interests …