AMPA receptor dysregulation and therapeutic interventions in a mouse model of CDKL5 deficiency disorder
M Yennawar, RS White, FE Jensen - Journal of Neuroscience, 2019 - Soc Neuroscience
Pathogenic mutations in cyclin-dependent kinase-like 5 (CDKL5) result in CDKL5 deficiency
disorder (CDD), a rare disease marked by early-life seizures, autistic behaviors, and …
disorder (CDD), a rare disease marked by early-life seizures, autistic behaviors, and …
CDKL5 deficiency in forebrain glutamatergic neurons results in recurrent spontaneous seizures
HT Wang, ZA Zhu, YY Li, SS Lou, G Yang, X Feng… - …, 2021 - Wiley Online Library
Objective Mutations of the cyclin‐dependent kinase‐like 5 (CDKL5) gene cause severe
neurodevelopmental disorders characterized by intractable epilepsy, intellectual disability …
neurodevelopmental disorders characterized by intractable epilepsy, intellectual disability …
Loss of CDKL5 in glutamatergic neurons disrupts hippocampal microcircuitry and leads to memory impairment in mice
Cyclin-dependent kinase-like 5 (CDKL5) deficiency is a neurodevelopmental disorder
characterized by epileptic seizures, severe intellectual disability, and autistic features. Mice …
characterized by epileptic seizures, severe intellectual disability, and autistic features. Mice …
Temporal manipulation of Cdkl5 reveals essential postdevelopmental functions and reversible CDKL5 deficiency disorder–related deficits
B Terzic, MF Davatolhagh, Y Ho, S Tang… - The Journal of …, 2021 - Am Soc Clin Investig
CDKL5 deficiency disorder (CDD) is an early onset, neurodevelopmental syndrome
associated with pathogenic variants in the X-linked gene encoding cyclin-dependent kinase …
associated with pathogenic variants in the X-linked gene encoding cyclin-dependent kinase …
Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder
S Tang, B Terzic, ITJ Wang, N Sarmiento… - Nature …, 2019 - nature.com
CDKL5 deficiency disorder (CDD) is characterized by epilepsy, intellectual disability, and
autistic features, and CDKL5-deficient mice exhibit a constellation of behavioral phenotypes …
autistic features, and CDKL5-deficient mice exhibit a constellation of behavioral phenotypes …
CDKL5 deficiency augments inhibitory input into the dentate gyrus that can be reversed by deep brain stimulation
Cognitive impairment is a core feature of cyclin-dependent kinase-like 5 (CDKL5) deficiency,
a neurodevelopmental disorder characterized by early epileptic seizures, intellectual …
a neurodevelopmental disorder characterized by early epileptic seizures, intellectual …
CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
CDKL5 deficiency disorder (CDD) is a severe epileptic encephalopathy resulting from
pathological mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene …
pathological mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene …
[HTML][HTML] X-linked cellular mosaicism underlies age-dependent occurrence of seizure-like events in mouse models of CDKL5 deficiency disorder
B Terzic, Y Cui, AC Edmondson, S Tang… - Neurobiology of …, 2021 - Elsevier
CDKL5 deficiency disorder (CDD) is an infantile, epileptic encephalopathy presenting with
early-onset seizures, intellectual disability, motor impairment, and autistic features. The …
early-onset seizures, intellectual disability, motor impairment, and autistic features. The …
Functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are rescued by a TrkB agonist
Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a severe X-linked
neurodevelopmental encephalopathy caused by mutations in the CDKL5 gene and …
neurodevelopmental encephalopathy caused by mutations in the CDKL5 gene and …
Molecular and synaptic bases of CDKL5 disorder
YC Zhu, ZQ Xiong - Developmental Neurobiology, 2019 - Wiley Online Library
The X‐linked gene cyclin‐dependent kinase‐like 5 (CDKL5) encodes a serine/threonine
kinase abundantly expressed in the brain. Mutations in CDKL5 have been associated with …
kinase abundantly expressed in the brain. Mutations in CDKL5 have been associated with …