Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats

RA Yokel, TC Au, R MacPhail, SS Hardas… - Toxicological …, 2012 - academic.oup.com
Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture,
and is being pursued as an antioxidant therapeutic. Our objective is to extend previous …

Nanoceria biodistribution and retention in the rat after its intravenous administration are not greatly influenced by dosing schedule, dose, or particle shape

RA Yokel, JM Unrine, P Wu, B Wang… - Environmental Science …, 2014 - pubs.rsc.org
A 30 nm ceria was previously shown to be primarily cleared from systemic circulation into
mononuclear phagocyte system organs after its intravenous (IV) administration, where it …

Bio‐distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice

SM Hirst, A Karakoti, S Singh, W Self… - Environmental …, 2013 - Wiley Online Library
Cerium oxide nanoparticles have oxygen defects in their lattice structure that enables them
to act as a regenerative free radical scavenger in a physiological environment. We …

Biodistribution and oxidative stress effects of a systemically-introduced commercial ceria engineered nanomaterial

RA Yokel, RL Florence, JM Unrine, MT Tseng… - …, 2009 - Taylor & Francis
The objective was to characterize the biodistribution of nanoscale ceria from blood and its
effects on oxidative stress endpoints. A commercial 5% crystalline ceria dispersion in water …

Exploring the long-term tissue accumulation and excretion of 3 nm cerium oxide nanoparticles after single dose administration

LM Ernst, L Mondragón, J Ramis, MF Gustà, T Yudina… - Antioxidants, 2023 - mdpi.com
Nanoparticle (NP) pharmacokinetics significantly differ from traditional small molecule
principles. From this emerges the need to create new tools and concepts to harness their full …

Persistent hepatic structural alterations following nanoceria vascular infusion in the rat

MT Tseng, Q Fu, K Lor… - Toxicologic …, 2014 - journals.sagepub.com
Understanding the long-term effects and possible toxicity of nanoceria, a widely utilized
commercial metal oxide, is of particular importance as it is poised for development as a …

Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria

SS Hardas, DA Butterfield, R Sultana… - Toxicological …, 2010 - academic.oup.com
Engineered nanoscale ceria is used as a diesel fuel catalyst. Little is known about its
mammalian central nervous system effects. The objective of this paper is to characterize the …

Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria

MT Tseng, X Lu, X Duan, SS Hardas, R Sultana… - Toxicology and applied …, 2012 - Elsevier
Beyond the traditional use of ceria as an abrasive, the scope of nanoceria applications now
extends into fuel cell manufacturing, diesel fuel additives, and for therapeutic intervention as …

Catalytic properties and biomedical applications of cerium oxide nanoparticles

C Walkey, S Das, S Seal, J Erlichman… - Environmental …, 2015 - pubs.rsc.org
Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the
test tube, cell culture models and animal models of disease. However given the reactivity …

Genotoxicity analysis of cerium oxide micro and nanoparticles in Wistar rats after 28 days of repeated oral administration

M Kumari, SI Kumari, P Grover - Mutagenesis, 2014 - academic.oup.com
The applications of cerium oxide nanoparticles (CeO2 NPs; nanoceria) extend to polishing
agents, diesel fuel additives and as a putative antioxidant in therapeutics. Therefore …