Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk
The plasma proteomic changes that precede the onset of dementia could yield insights into
disease biology and highlight new biomarkers and avenues for intervention. We quantified …
disease biology and highlight new biomarkers and avenues for intervention. We quantified …
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life
A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
[HTML][HTML] Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment
Cognitive impairment in the elderly features complex molecular pathophysiology extending
beyond the hallmark pathologies of traditional disease classification. Molecular subtyping …
beyond the hallmark pathologies of traditional disease classification. Molecular subtyping …
Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia
Objective Previous gene expression analysis identified a network of coexpressed genes that
is associated with β‐amyloid neuropathology and cognitive decline in older adults. The …
is associated with β‐amyloid neuropathology and cognitive decline in older adults. The …
Cerebrospinal fluid proteomics and biological heterogeneity in Alzheimer's disease: a literature review
KEJ Wesenhagen, CE Teunissen… - Critical reviews in …, 2020 - Taylor & Francis
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
aggregation of amyloid and tau proteins in the brain. Results from genetic studies suggest …
aggregation of amyloid and tau proteins in the brain. Results from genetic studies suggest …
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and
progression of Alzheimer's disease (AD) would have great utility; potentially clinically, but …
progression of Alzheimer's disease (AD) would have great utility; potentially clinically, but …
Plasma proteomic profiles predict future dementia in healthy adults
Y Guo, J You, Y Zhang, WS Liu, YY Huang, YR Zhang… - Nature Aging, 2024 - nature.com
The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease
Proteomic studies for Alzheimer's disease (AD) are instrumental in identifying AD pathways
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …
[HTML][HTML] Alzheimer disease pathology and the cerebrospinal fluid proteome
Background Altered proteome profiles have been reported in both postmortem brain tissues
and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with …
and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with …
[HTML][HTML] Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein
posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the …
posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the …